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ey0016.6-19 | Transgender Reviews | ESPEYB16

6.19 Management of endocrine disease: approach to the management of children and adolescents with gender dysphoria

L Martinerie , A Condat , A Bargiacchi , C Bremont-Weill , MC de Vries , SE Hannema

Eur J Endocrinol. 2018 Oct 12;179(5):R219R237.doi: 10.1530/EJE-18-0227. PubMed ID: 30049812The rapidly increasing number of adolescents with gender dysphoria represents a challenge for psychiatric assessments and the endocrine management of those who are considered to warrant gender change. The diagnostics are more than complicated and the clinical management from ...

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ey0018.6-16 | Longterm Effects of Hormonal Treatments in Gender Dysphoria | ESPEYB18

6.16. Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study

A Weill , P Nguyen , M Labidi , B Cadier , T Passeri , L Duranteau , AL Bernat , I Yoldjian , S Fontanel , S Froelich , J Coste

BMJ. 2021 Feb 3;372:n37. doi: 10.1136/bmj.n37. PMID: 33536184This observational cohort study used data from the French administrative healthcare database during 20072015 to assess the risk of meningioma development related to treatment with cyproterone acetate. The cohort comprised 253,777 participants, of whom 54% had high exposure to cyproterone acetate, and 45% had low exposure.<p cla...

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ey0017.11-2 | New Genetic Findings | ESPEYB17

11.2. Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension

M Baron , J Maillet , M Huyvaert , A Dechaume , R Boutry , H Loiselle , E Durand , B Toussaint , E Vaillant , J Philippe , J Thomas , A Ghulam , S Franc , G Charpentier , JM Borys , C Levy-Marchal , M Tauber , R Scharfmann , J Weill , C Aubert , J Kerr-Conte , F Pattou , R Roussel , B Balkau , M Marre , M Boissel , M Derhourhi , S Gaget , M Canouil , P Froguel , A Bonnefond

To read the full abstract: Nature Medicine. 2019;25(11):17338. PMID 31700171.These authors sequenced the gene for melanocortin-2 receptor accessory protein (MRAP2 ) in 9418 blood DNA samples from several population studies. They detected 23 rare heterozygous variants, which were significantly associated with an increased risk of obesity (OR 3.8 in children and 2.9 in adults)....

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ESPE Yearbook of Paediatric Endocrinology

6.19 Management of endocrine disease: approach to the management of children and adolescents with gender dysphoria

6.16. Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study

11.2. Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension

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